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The real responsive design challenge? RSS.
If you host an RSS or Atom feed then load it in a variety of readers and see how it looks. Here are ones I’ve noticed who hit my site: Newsbeuter, Newsflow, Sismics reader, Tiny Tiny RSS, Feedly, Feedbin, Akregator, Feed Wrangler, NewsBlur, FeedHQ, Feed Spot, Livedoor reader, Miniflux, Liferea, Readerrr, and Mozilla reader.
The first thing you’ll notice is that they disregard Javascript and CSS but preserve images. Sometimes they add their own CSS, other times they leave the document completely unstyled. Taking control of the style allows these programs to offer adjustible line spacing and switchable themes like a darkened night browsing mode. You may not have seen your site without any CSS clothes for a while, and may realize it needs to go to the markup gym.
