It's 2018 and a lot has changed, some good and some bad.
As of now, what are you finding as you visit sites, from an AdSense perspective, that seems to frustrate you the most.
For me. and you can consider this as publishers being greedy or forgetting the old "less is more" rules, but it's when I am invited to read an article, report or whatever, I go there as invited and other than enjoy the reading, I seem to constantly fight with ads, in many sizes and locations, blocking part of what I am there to read.
FarmBoy