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Here is a list [unt.edu] of commands to move around Internet Explorer.
After my previous JAWS experience, I really have a different perspective for the disabled. Man, what a nightmare that was, browsing various sites using JAWS. And then I decided to browse sites in the SEO arena. Yikes! SHUT UP!
Lynx is a great test tool as well, as it strips down the page to the bare essentials. If your page works well in Lynx, then you have gone a long way to making it accessible via a screenreader.
A hint: use VMWare or a similar virtualization program to have multiple instances of you OS available with different configurations. In that way, you can test such software without affecting your main setup.