If the latter is the case then this question is for US publishers, when building a new website do you consider building it around Adsense or YPN, (i.e creating the site to host blending Contextual Ads). I am in the process of building a site specifically for YPN. However a good topic/domain name eludes me. I have chosen real estate of course I think it is most competitive especially in hot spots in the states. But tell me if I am barking up the wrong tree here.

In the posts I have seen the fundamental issue has been poor delivery of related ads. This will be the case because YPN does not have the depth of advertisers, arbitrage webmasters, etc as Google does. But if webmasters focus on creating a website that YPN does hav a lot of advertisers for then I don't see the problem.

Take for example the keyword Real Estate. There are over 50 states and not to mention cities, counties, boroughs, etc across the USA. Most of the topic related sites are already held by scrapers with simple ads up no real content. If you cant get the .com take the .net and beat these sites. The keyword real estate will yield:
real estate insurance
refinancing
mortgage loans
real estate agents.........

And the list goes on. Following Bretts 26 steps you can easily create over 100 pages of fresh content well put together. These pages can all host relevant YPN ads where competition and advertisers are in good bounty.

However one must look on the downside of YPN; the worst one being they dont want you to show ads to non usa browsers. I have to figure a way around this because I don't know how the heck to stop that.

My opinion Made For YPN sites must work better than MFA's because if built on the right topic with good content they pay better.