OK, I think I found something interesting with Effective Search.
In Containing Text, I search for 00 (in Hex code) + AND not 30 + AND not 61 + AND not 65 (or anything else).

Run [as administrator] the System File Checker. It only checks and repairs....

sfc /scannow

System file check (SFC) Scan and Repair System Files & DISM to fix things SFC cannot

[answers.microsoft.com ]

My problem started early summer 2016. I have my data drives (D,E,F,G, H) that I connect to my motherboard during winter, and during summer, I bring to my chalet to connect to my laptop. I do not know what happened, but somehow files got corrupted. I got this message by Windows to run scan because it detected problems with files. I ran it, and after I realized that many of my files were stripped of their content by replacing data with hex 00 to (same file size). As you might think, I do not want to reproduce the same problem this year. This is why I want to scan files before overwriting the previous version.
Thanks

This is why I want to scan files before overwriting the previous version.

My suggestion above only deals with corrupted Windows system files on your boot drive - which was what I thought was your problem.

Corrupted data files elsewhere? Whoa - you have a setup similar to mine, and you have a real problem. Are all your other drives separate physical drives, logical drives or a mix?

What version of Windows? What virus protection do you have? Surely you have Windows Defender.

I would at a minimum disconnect all drives except for your boot drive. Then for Windows 10 I would go to Settings/Update & Security/Windows Defender/Open Windows Defender

You can do a quick scan first - then a full scan that can take a long time - in your case I would invest in that time.

Next you might need to look at data recovery options.You are living my nightmare, where backup for me is a financial impossibility for 17TB over 7 drives.

17TB over 7 drives ... wow!
What I think happened in my case, is I connected my SSD (containing 5 partitions, D,E,F,G,H) through a USB cable to my laptop. I always click the [Safely Remove Hardware] before disconnecting drive, but may be doing this causes a problem with files (FAT). What was weird is that the files were ok on my laptop, but when brought back to my home computer, that is when the scanning and repair problems happened.
Anyways, I will proceed differently this summer.
My laptop is on Windows 10, my home computer used to be on Windows 10, but now is on Windows 8.1

SSDs are great but not the best medium for long term R/W storage. Backups are more reliably stored on traditional hard drives or even cloud storage.

Some reference reading:
[webmasterworld.com...]
[webmasterworld.com...]
and an article from that last thread:
[usenix.org...]

I do not only rely on SSD. I got my system backup daily and weekly on traditional hard drive. I have a batch file to robocopy files on one of my hard drive (mirror).
Thanks for the references.