So here are short reviews of Ad Networks that I work with or have worked with.
Google Adsense: Still one of the better ones but not my top earner anymore. Best if you use just one link unit and two ad units from my experience. Great in premium positions, terrible in non-premium positions.
Nativo: Good-looking native ads. If placed in high-CTR positions, it can beat Adsense. Currently my top earner.
Sekindo: Non intrusive video ads. Very high RPM for desktop and tablet and can be placed in low ad positions.
Media.net: low rpm at first but leave an ad in a premium spot for 2-3 weeks and the RPM skyrockets if your account rep stays engaged and knows what they are doing. Good for non-premium ad placements.
Kixer: Requires a good deal of experimentation but can produce gigantic RPM if your site has heavy mobile traffic. Best non-intrusive interstitial I've seen.
Connatix: just started with them. Okay to mediocre RPM. Ads are like a cross between Nativo and Sekindo. RPMs are supposed to climb substantially after awhile like media.net so I'll wait and see.
Content.ad: good RPM for a "clickbait" sponsored content provider but ads can be a bit #*$!y unless set to "PG" instead of PG13 or R.
Adblade: used to be as good as Content.ad but gone severely downhill as far as RPM.
Newsmax Feed Network: killer CPC (double content.ad) but only tried the links-only unit with no images. About to start experimenting with the images unit. Will see how CTR is.
Taboola: garbage RPMs. Can't see why it's so popular. Rumor has it that more premium publishers get better RPM than small and medium timers.